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These patients were deemed not suitable for escalation to level 3 care.
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Second, carbon ion therapy may be suitable for dose escalation and hypofractionation.
Furthermore, carbon ion therapy may also be suitable for dose escalation and hypofractionation.
Unfortunately, some of the most effective drugs in breast cancer, namely anthracyclines and taxanes, are not suitable for dose escalation to the same extent because of the cardiotoxicity of anthracyclines and neurotoxicity of taxanes.
McNamara are in no mood for escalation.
But the pressure for escalation will continue to mount.
But the capacity for escalation has not gone away.
"We are not for escalation.
The risks for escalation of tensions are significant.
Moreover, the classical dose escalation rules (i.e. Fibonacci escalation, 3+3 design, dose-effect and dose-toxicity relationships) may not be suitable for MTA phase 1 trials.
Suitable for over-threes.
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