Activating mutations of the α-isoform of PI3K (p110 α) occur with frequencies of up to 30% in cancer and, recently, mutated p110 α was suggested to render cancer cell lines resistant to TRAIL-induced apoptosis.
This particular feature has been suggested to render these groups of organisms especially conducive to sexual selection and, therefore, to have favoured the elaboration of male secondary sexual characters [ 42].
The TCI is based on a self-report questionnaire and comprises seven dimensions, two of which have been suggested to render the individual more prone to develop depression – harm avoidance (being high in subjects at risk for depression) and self-directedness (being low in these subjects) [ 29].
The many anecdotes of Boone's tenure as syndic suggest he sought to render fair judgments rather than to strictly observe the letter of the law.
This transformation is suggested to be critical toward rendering gluten immunotoxic.
Changes in the activation energy are suggested to affect release probability by rendering vesicles more/less fusogenic (Basu et al., 2007; Wierda et al., 2007; Gerber et al., 2008; Xue et al., 2010).
I'm not sure anyone has convincingly made the same argument about synthesizers — suggesting that they have managed to render analog instruments irrelevant — though many have expressed displeasure at their proliferation.
We found the folding machinery to be activated at all tested stress levels, while cbh-1 and cbh-2 were dramatically down-regulated at concentrations exceeding 0.1 mM DTT or 5 μg/mL TM, respectively, suggesting an induction of RESS to render cells more resistant against acute ER stress.
Taken together, the findings suggest to Kipnis that MECP2 mutations render microglia unable to do their custodial duties, resulting in a buildup of debris that interferes with the function of neurons.
The main obstacle to its integration is clearly vagueness, and paradoxes that emerge from attempts to render justification precise probabilistically suggest many epistemic concepts and issues will require reconceptualization in formal epistemology (see Shogenji 2012).
