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The selective deletion of the first reaction centre cysteine residues that are structure-level-paired but sequence-level-distant in PI-II illustrates the flexibility of PI-II domains and suggests the functionality of their transient gene versions during evolution.
The fact that Glu16 also impairs HOIP activity also suggests the functionality of this side chain in assembly reactions.
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In this study, several evidences suggest the functionality of these HGT genes for shrimp.
RNAz alignments show a high inter-lineage conservation and multiple compensatory base changes in the stem regions (supplementary figs. S10 S17, Supplementary Material online), which suggest the functionality of the structures.
Figure 3B shows that mutation of the Grb14 FLVRS motif abolishes tyrosine phosphorylation of Grb14 suggesting the functionality of this domain must be intact for Tie2 mediated Grb14 tyrosine phosphorylation.
We suggest the functionality-based classification of metasurfaces, and clarify a link between their polarization response and field control capabilities.
However, detection of the ORFs for nuclear sdh3 rps10 rps14 and plastid rpl2 suggests the possibility of functionality.
In summary, the association of PCOS with Hp2 alleles of haptoglobin suggests that the functionality of this protein might be altered in these women, even when its circulating concentrations are not altered because their insulin resistance counteracts the decrease in circulating haptoglobin usually associated with Hp2 alleles.
Our analysis suggests that the functionality of binding is highly condition-specific and highly dependent on the presence of specific cofactors.
This difference is particularly striking on synonymous positions, suggesting that the functionality of this predicted protein was maintained by natural selection following its transfer to the virus, but a difference nevertheless remains on non-synonymous positions once the synonymous changes are removed (4-fold degenerate codons, p<10−5).
These mutations impair DJ-1 homodimerization, suggesting that the functionality of the protein is perturbed.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com