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We identified 4 SNPs in the estrogen receptor gene (ESR1) on chromosome 6q25.1 with suggestive signals of association (p<0.05) with standing body height.
A genome wide association study (GWAS) typically results in a few highly significant 'hits' and a much larger set of suggestive signals ('near-hits').
Genomewide suggestive signals are indicated in bold.
Borderline genomewide suggestive signals are bold and italicized.
In the current study we tested previous suggestive signals for DN for association with SDR.
However, several loci, including 15q24, 17q12 and 8p23, showed suggestive signals of SNP-allele correlation.
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Another suggestive signal observed in Meta 1 was rs17057381 (P-value = 4.02 × 10-7) on chromosome 8.
The third suggestive signal observed in Meta 1 was a broad region of association on chromosome 14.
Another suggestive signal was obtained at cg21046959 directly in LINC00340, and the LINC00340 transcript has been linked to both neuroblastoma and ovarian tumours [ 38, 39].
The second suggestive signal in a cancer-related gene was obtained at cg21046959 in LINC00340, and showed hypomethylation in cancer-affected twins.
A non-parametric SNP-based linkage analysis performed using the Merlin program [24] did not give significant or suggestive linkage signals (maximum LOD score of 1.62 for chr14: 27.526–29.525 Mb), further suggesting a complex mode of inheritance with possible multiple low risk susceptibility loci, rather than a risk attributable to a major gene(s).
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CEO of Professional Science Editing for Scientists @ prosciediting.com