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This has led to the suggestion that the function of the chitinous eggshell is restricted to mechanical support of the developing embryo from gastrulation onwards.
Our results bring forward the controversial, although intuitive, suggestion that the function of a protein may change across an evolutionary scale leading to a plastic fitness landscape in which constraints on amino acids can vary dramatically.
The residues of the brooch mediate interactions between the 8 kDa domain and the thumb subdomain, leading to the suggestion that the function of the brooch is to facilitate enzyme substrate interactions during synthesis to fill gaps longer than one nucleotide.
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Conservation of expression patterns of barley clock orthologs under LD and LL support the suggestion that clock orthologs function in the circadian clock in barley.
Even in their advocacy, Parsons and Carlson caution against the suggestion that function solely determines form, as that would neglect other features of artifacts not possibly highlighted by their functions.
Gcn5 is localised to S. cerevisiae genes that require its activity for their repression as well as for activation, thus providing support for the suggestion that Gcn5 can function as a direct repressor of gene activity in addition to its characterized role as a transcriptional coactivator.
Examination of the CCP proteins for Pfam domains [ 36] which include ubiquitanases, AAA+ domain containing proteins, protein kinases, tubulin-tryosine ligases and phosphatidic acid phosphatases, supports the suggestion that ancestral ciliary function proteins have been co-opted in land plants to perform cytoskeletal roles.
The increased EGFR/LRIG1 ratio found in RCC lends support to the suggestion that LRIG1 functions as a tumour suppressor and inhibitor of EGFR in humans.
Loss of DUSP6 expression due to promoter hypermethylation is associated with the progression from the pancreatic intraepithelial neoplasia to invasive ductal carcinoma, leading to the suggestion that DUSP6 functions in this cancer type as a tumour suppressor (Furukawa et al, 2003).
In addition, our analysis suggests that neither Trs130 nor TMEM1 is a trans-membrane protein, arguing against the suggestion that TMEM1 functions as a membrane channel.
This strict association led to the suggestion that HEPN domains functioned in conjunction with the associated MNT domains.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com