Sentence examples for suggestion that activation of from inspiring English sources

In contrast, the structures of agonist-bound, active GPCRs show no space for a Na+ ion, which has already prompted a suggestion that activation of these GPCRs might be coupled with the release of the sodium ion to the opposite, cytoplasmic side of the membrane [ 27, 82 ].

This has led to the suggestion that activation of pro-survival pathways may occur in association with pro-apoptotic pathway activation and that septic cardiomyopathy, although ultimately dysfunctional for the organism, is a reactive process of metabolic downregulation, serving a cellular preservation function broadly similar to preconditioning [6].

These findings led to the suggestion that activation of calcineurin in slow muscles, or muscles subjected to slow stimulation, dephosphorylates and activates MEF2, which binds to and transactivates the slow but not the fast troponin I promoter (Wu et al., 2000).

Our findings in the Jurkat cells provide the first suggestion that activation of pro-apoptotic p73 also couples transcriptional inhibition to apoptosis in keeping with a recent demonstration of the ability of p73 to directly induce cytochrome c release from isolated mitochondria[ 60].

There have been suggestions that activation of PI3K regulates the migration and invasion of various cancer cells (Reiske et al, 1999; Zeng et al, 2006).

Although this orientation-dependent activation hypothesis for single transmembrane receptors was initially debated because of the suggestion that other properties of this EPO mimetic could result in loss of activity [ 40], subsequent studies supported that activation of single transmembrane receptors might be beyond a ligand-induced encounter of the cytoplasmic domains.

They thought that activation of the brain stem might play a role in the onset of migraine pain.

The conformation of Ig3 also changes on inhibitor binding, leading to the suggestion that MALT1 activation is a two-step process relying on both dimerization and, on substrate binding, release from Ig3-mediated autoinhibition [ 69].

These findings support the suggestion that dopaminergic activation in the ventral pallidum is involved in ethanol-seeking and ethanol-drinking behaviors and directly implicate the mesopallidal dopamine system in the reinforcing actions of ethanol.

30 However, there was a suggestion that this effect of suppression of the activation of microglia was age-dependent or disease stage-dependent, being not significant in patients with advanced Alzheimer's disease.

There is suggestion that ipsilateral activation of the hypothalamus during cluster headache attacks stimulate ipsilateral but simultaneously suppress contralateral TAR [9].