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The identified miRNAs: hsa-miR150-5p hsa-miR150-5p hsa-miR150-5p7a-3p all could serve as potential biomarkers for disease stages in MG and we suggest validation of these biomarkers in a larger international cohort for diagnostic and therapeutic purposes.
Moreover, due to the extended enrolment period, the PCR assay used in our study for on-treatment serum HCV-RNA assessment had a relatively high limit of detection (50 IU/mL) that could have misclassified some RVR patients and suggests validation of our results with an HCV RNA assay with a lower detection limit [ 29, 30].
In addition, it is suggested validation in a larger number of samples for overcoming errors from multiple testing.
This paper provides recommendations on best practices for the validation of cell-based NAb assay and suggested validation parameters based on the experience of the authors.
The computed response spectra at selected locations were similar to those from the full-scale measurements, suggesting a validation of the predictions.
A recent transcriptome profiling study also found many clusters of reads that mapped to unannotated regions of the Ae. aegypti genome [44] suggesting empirical validation of transcribed units using next-generation sequencing should be used to complement in silico gene prediction pipelines.
Although the number of transcripts validated is small, these results suggest that validation of mRNA between the array and qRT-PCR assay are concordant with each other specially in transcriptome profiling.
However, given this study's limitations, we suggest prospective validation of these findings.
The findings of this meta-analysis suggest that validation of a revised set of classification criteria for GCA which will include the halo sign is warranted.
We acknowledge the modest size of our cohort but suggest that validation of these promising findings in additional prospective studies is now warranted.
These encouraging results suggest a validation of the role of DW-MRI for recurrent prostate carcinoma on a larger scale, as an earlier diagnosis and a more accurate intraprostatic mapping of the recurred prostate cancer after radiation therapy can provide better selection of the appropriate second-line treatment.
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