The Beclin-1 protein is essential for the initiation of autophagy, and recent studies suggest this function may be compromised in Alzheimer's disease (AD).
The existence of EPS-8B-like isoforms in Drosophila suggests this function of EPS-8 proteins could be conserved among other organisms.
Indeed, the clear association of Nod2 polymorphisms with defective bacterial killing suggests this function could significantly underlie the contribution of commensal flora to the pathogenesis of Crohn's disease.
The correlation of its activity with DNA degradation suggests this function.
Each of these genes are oxoglutarate-dependent dioxygenases, and several unigenes suggest this function, as revealed by GO annotation.
All sporulation-controlling sigma factors (σA, σE-H, and σK) were detected in all Lachnospiraceae genomes, which suggests this function was present in the ancestor of the group.
However, preliminary models suggested this function to be too non-disciminative; we found that a cubic exponent yielding ω u, v) = (cor(m u, m v 3 enhances the resolution, with values well spread out in the interval [0, 1].
The overlap in content with "sensory perception of sound" given genes such as TMIE (trans-membrane of inner ear), and components of the otolith (OTOF and OTOS) suggests this function is also essentially related to inner ear development.
Upregulation of STAT3 levels in various cancers (Garcia et al, 1997; Bromberg et al, 1999; Bowman et al, 2000; Song and Grandis, 2000) might even suggest this functions as an 'oncogene' or 'tumour progression' gene.
