The selective deletion of the first reaction centre cysteine residues that are structure-level-paired but sequence-level-distant in PI-II illustrates the flexibility of PI-II domains and suggests the functionality of their transient gene versions during evolution.
In this study, several evidences suggest the functionality of these HGT genes for shrimp.
The fact that Glu16 also impairs HOIP activity also suggests the functionality of this side chain in assembly reactions.
RNAz alignments show a high inter-lineage conservation and multiple compensatory base changes in the stem regions (supplementary figs. S10 S17, Supplementary Material online), which suggest the functionality of the structures.
This difference is particularly striking on synonymous positions, suggesting that the functionality of this predicted protein was maintained by natural selection following its transfer to the virus, but a difference nevertheless remains on non-synonymous positions once the synonymous changes are removed (4-fold degenerate codons, p<10−5).
These mutations impair DJ-1 homodimerization, suggesting that the functionality of the protein is perturbed.
The reverse function of FoF1, ATP-dependent proton-pump activity, was also detected (Supplementary Fig. 8), suggesting the full functionality of the reconstituted FoF1-PLs.
These data suggest that the functionality of available receptors may be reduced by higher coupling of PSD95 to the 5-HT2CR in the mPFC of HI vs LI rats (Abbas et al, 2009; Becamel et al, 2002; Gavarini et al, 2006).
In summary, the association of PCOS with Hp2 alleles of haptoglobin suggests that the functionality of this protein might be altered in these women, even when its circulating concentrations are not altered because their insulin resistance counteracts the decrease in circulating haptoglobin usually associated with Hp2 alleles.
This may suggest that the functionality of the Golgi apparatus has evolved and matured fairly early in the plant evolution.
