Notably, the short interspersed repeats and the 3'-UTR VNTR polymorphism of the SLC6A3 reside in the same region, suggesting the complexity of possible biological effects of sequence variations occurring therein.
Interestingly, a slight increase in thigmotaxis (tendency to swim near the walls of the water maze) in the Ts65Dn mice was also reversed by DAPT (Fig. 2d), suggesting the complexity of the cognitive and behavioral phenotype that might be affected by Aβ.
Although some well-investigated lipogenic transcription factors including Srebf1 were not altered, many critical regulators in lipid metabolism such as Scd1, Acacb (also known as Acc2), Fasn (also known as Fas), Fabp5, Ppard, Acss2, Hmgcs1, Cyp51 and Sc5d were found as the down-regulated genes (Table S4, Figure 4A, 4E), suggesting the complexity of the molecular pathology of the KRAP−/− mice.
In addition, their structural and functional characteristics were closely related, and suggesting the complexity of the cell regulatory system.
Besides, genes responding to chemicals, such as toxin, nutrient and hormone were also found, suggesting the complexity of biological regulation of tobacco trichomes.
RORα is bound by hydroxyl-cholesterol, while Rev-erbα is bound by heme, suggesting the complexity of modulators of circadian rhythmicity.
It somehow suggested the complexity of everything, the contradictoriness.
The "Cathedral" series of 1892-95 suggesthethe complexity of the work in this show.
"What the film is trying to do in general is to suggest the complexity of the problem".
At Dixon, a simple sign suggests the complexity of the challenge: "Teach half as much, twice as well".
And the glances alone, in a fascinatingly simple-looking duet for Ms. Viola and Michael Trusnovec in the eighth part (to Alfred Schnittke), suggest the complexity of love.
