PEGylation of these polypeptides does not alter the self-association or conformational behavior of the polypeptide, suggesting potential applications in the development of assembled delivery vehicles, as modification of the polypeptides should be a useful strategy for controlling assembly.
The resulting compounds demonstrated PDE4 inhibitory activity in cell free and cell-based assays comparable to the Zardaverine control used, suggesting potential avenues for their further development.
also serve as liaisons towards the European Commission, giving advice with respect to specific areas of interest and their respective needs for further development and also suggesting potential future directions that the European Commission should pursue.
This suggests potential for development of a hybrid model that accommodates both pieces of information and that future studies test assumptions of rate autocorrelation before invoking them, at least for the tree depth that we consider here.
These findings show that neointestinal mucosa can be maintained for at least 12 weeks on a subcutaneous PLGA scaffold, and the presence of actively proliferating cells at 12 weeks suggests potential for further development beyond this.
Our research on the mechanistic role of Gcn5 in regulating FLO11 expression and pseudohyphal development suggests potential therapeutic targets for treatment of fungal diseases.
Subsequent studies have supported the role of anti-Ro antibodies (both Ro52 and Ro60) in congenital heart block and suggested potential mechanisms for the development of the condition [ 21, 22].
These findings implicate inflammation as a key contributory factor in Goldmann-Favre syndrome and suggest potential targets for the development of therapies relevant to this and related neurodegenerative disorders.
This analysis suggests potential barriers to the development of home haemodialysis programmes specific to regions without active home haemodialysis services that include structural barriers, competing treatment choices and services, the role of the clinician in care and cultural perspectives within health delivery.
Thus, their increased expression suggests potential roles in OL maturation and normal oligodendritic development.
