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Recently, formic acid has also been suggested to trigger the acid crash of butanol production by C. acetobutylicum (Wang et al. 2011).
Genetically-based loss of tolerance toward the gut flora was suggested to trigger the formation of anti-microbial antibodies in Crohn's disease [45].
This in turn is suggested to trigger the innate and adaptive immune response.
Free radicals and localised ischaemia have been suggested to trigger the proliferation of DD tissue.
Several molecules have been suggested to trigger the latter (De Felice et al, 2009; Shankar et al, 2007; Snyder et al, 2005).
Accumulating extracellular acetate upon deletion of ACH1 (Fleck and Brock, 2009; Orlandi et al., 2012) has been suggested to trigger the death of ach1 mutant cells (Orlandi et al., 2012).
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Sex hormones are suggested to trigger these sex specific differences [ 2].
Ubiquitination of VDAC1 is suggested to trigger recruitment of the autophagy adaptor p62/SQSTM1, in a role similar to that it performs in the cytosol, where it essentially 'chaperones' ubiquitinated proteins to the proteasome, activating recruitment and conjugation of the phagophore, and ensuring encapsulation and eventual turnover of the damaged mitochondrion (Geisler et al., 2010).
The pathogenic role of cdt A/B has been suggested to trigger microtubule protrusion, thereby increasing the adherence of C. difficile to the gut epithelium [ 4]. C. difficile infection (CDI) results in a wide range of symptoms including fever, abdominal pains, mild diarrhea, and pseudomembranous colitis.
In response to strong TCR signals, MAPKs are suggested to trigger death pathways mediated by the BCL-2 family member BIM and the orphan nuclear receptor NUR77, respectively.
Indeed, 5-hmC was suggested to trigger passive demethylation through inhibition of the maintenance methyltransferase DNMT1 (Valinluck and Sowers 2007).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com