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The mitochondrial uncoupling proteins-1, -2 and -3 are suggested to play essential roles in energy dissipation and disposal of excess lipid.
Furthermore, some metals, such as iron and copper, have long been suggested to play essential roles in the dopaminergic system, and, these metals are required for dopamine production (McCann and Ames 2007).
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Indeed, the conserved phosphate-binding loop serine residue has been suggested to play an essential role in stabilizing the enzyme-substrate complex (Fig. 2A) [2A].
Furthermore, Wnt signaling has been suggested to play an essential role in osteogenesis in vitro and in vivo [ 23– 25].
This family was recently suggested to play an essential role in lignification and plant development [ 23- 25].
The non-helical tailpiece has been suggested to play an essential role in the initiation and modulation of filament assembly [ 38].
Especially, Cath-B has been suggested to play an essential role in TNF-mediated apoptosis (Leist and Jaattela, 2001), and has been proposed to represent a therapeutical target in cancer therapy of tumours with elevated levels of cysteine proteases (Foghsgaard et al, 2001).
Leukocyte infiltration of brain tissue and the subsequent inflammation, demyelination, axonal damage, and formation of sclerotic plaques is a hallmark of MS. Upregulation of proinflammatory cytokines has been suggested to play an essential role in regulating lymphocyte migration in MS. Here we present data on serum cytokine expression in MS cases.
It is suggested that helicases play essential roles in stabilizing growth in plants under stress because their presence in the stress-induced ORFs has been identified.
A large number of studies have suggested that miRNAs play essential roles in biological processes and might correlate with specific clinical features of breast cancer, such as estrogen and progesterone receptor expression, tumor stage, vascular invasion, and proliferation index.
Such coordinate regulation suggests they play essential roles during these phases of the chlamydial cell cycle.
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