AQP1 has been suggested to function as an ion channel upon cGMP activation, although this idea has been controversial.
For example, three copies of an E-box element defined by the core motif 'CANNTG' has been suggested to function as JA-responsive enhancer within −515 to −265 region of rice chitinase gene OsChia4a (Table 2).
Heterochromatin maintenance has been suggested to function as a self-reinforcing feedback loop, as new siRNAs are formed from the occasional nascent transcripts by RdRP for incorporation into local RITS complexes.
CDH13 has been suggested to function as a negative regulator of neural cell growth [69].
Bcl11b has been suggested to function as tumor suppressor in cells, primarily based on human loss of homozygosity (LOH) studies.
Lipid rafts have been suggested to function as platforms connecting receptor complexes and their signaling pathways [14].
In addition to HSPGs, α6 integrin as well as laminin 5 have been suggested to function as transient receptors for HPV [8] [10].
In this regard, exosomes have been suggested to function as immune-response modifiers because these vesicles are secreted by many types of tumors cells.
The remaining 10 genes have not been investigated in ovarian cancer and include SFPQ which has been suggested to function as an androgen receptor co-regulator [57].
HCEs thus have frequently been suggested to function as cis-regulatory elements, and several HCEs have been tested as cis-regulatory modules of genes for early development [2].
Thus, miR-206 is suggested to function as a suppressor of breast cancer metastasis [23], although the mechanism remains to be defined.
