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Regarding gene body methylation, body-methylated genes have been suggested to be functional important and represent housekeeping functions (Sarda et al. 2012; Takuno and Gaut 2012).
On the other hand, HR has been suggested to be functional on Top2 poisons-induced irreversibly DNA damaged cells [32].
Since Mib and Neur share biochemical functions and their mutants show similar phenotypes, these two proteins were suggested to be functional homologues between species [10].
Several of these repeat subclasses have been previously suggested to be functional as well [ 28- 30].
Although some miRNA originating within repeats were suggested to be functional [ 31, 32], proving this would require further evidence.
Only two alleles HLA-E*0101 HLA-E*0101*0103) and HLA-E*0103 HLA-E*0103pulareons, and suggested to be foundinnal differences betworldwidee variants.
Similar(53)
The pea (Pisum sativum) gene PEAM4 seems to be the closest to AP1 in function and has been suggested to be a functional homologue of AP1 [ 23] based on similar expression pattern and floral phenotype.
Additional sequence patterns occurring within the effector domain, called K, L, W and Y motifs, have been identified and suggested to be important functional elements [22], [24].
IBS is suggested to be a functional disorder [ 17- 19].
Autophosphorylation at the activation segment residue T180 has been suggested to be of functional importance for DAPK3 activity, because a T180A mutant is resistant to activation and suppresses DAPK3 function in cells (Graves et al, 2005).
While PTHrP and PTH genes have been identified in teleosts and tetrapods, PTH-L seems to be absent from eutherian mammals and it was recently suggested to be the functional homologue of mammalian PTH, in fish [ 5].
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