Low transcription activity of the moderately silenced genes (Fig. 2C E) suggests repression in many, if not all, cells of the population.
Downregulation of these core pathway components suggests repression of the basal response to growth factors, an effect that appears to be amplified by upregulation of the Ras inhibitor, NF1 (⇑1.81) and the ERK1/2 inhibitor, PTPN5, (⇑1.59).
Cells that were transfected with different concentrations of lu-VUTR always produced lower levels of luciferase activity than cells transfected with a control construct (Fig S3a), suggesting repression of luciferase expression by endogenous miRNAs.
The majority (243 genes) were downregulated in SRBCTs, suggesting repression by EWS-FLI1.
Furthermore, without suggesting repression as explanation, it is difficult to interpret why emotional defensiveness Table 3, footnote a was associated with a high level of support.
In both the heart and the kidney, daily torpor led to inhibition of the mTOR pathway, suggesting repression of protein synthesis.
Similarly, we observed down-regulation in the category of a dehydrogenase-like aldehyde dehydrogenase, glutamate dehydrogenase, suggesting repression of fermentative pathways.
In contrast, extracts lacking XPol κ (ΔXPol κ) displayed a high degree of UV-resistant DNA synthesis that was not enhanced by addition of caffeine, suggesting repression of the replication checkpoint.
In our studies, combined GO and manual analyses revealed trends of hypoxia-regulated differentiation markers that suggest repression of adipogenesis and myogenesis in favor of osteogenesis, angiogenesis and hematopoiesis.
In NKX2-5 mutant embryos, the majority of differentially expressed genes were down-regulated (suggesting that these were positively-regulated targets of NKX2-5) alimited a limited number of progenitor genes were up-regulated in the transition from progenitor state to differentiated cardiomyocytes, suggesting repression of some targets.
