At physiological concentrations, progesterone and the pure progestin, Org2058, displayed the most potent H2O2 detoxification ability suggesting its effect was characteristic of its progestin potency.
Although BCG protects against severe forms of TB in childhood, increasing rates of the disease in adults suggest its effect is not long-lasting.
However, a mutant within the UP site, which abrogates 53BP1 binding based on bandshift and ChIP assays, still responds to 53BP1 overexpression, suggesting its effect may be indirect.
It has been reported to inhibit the KATP channels of β cells, cardiomyocytes, and nonvascular smooth muscle cells with similar affinity, suggesting its effect on myocardium (18, 19).
This suggests its effect is either directly on the channel or via long-range membrane-delimited effects, for instance through a change in membrane tension or curvature of the membrane.
As Gerard Roe of the University of Washington argues, even if climate sensitivity were as high as the IPCC suggests, its effects would be minuscule under any plausible discount rate because it operates over such long periods.
But a new study suggests its effects were felt even farther away—in Antarctica.
Research delineating mechanisms by which stigma leads to poor HIV treatment outcomes is less common, but several formative studies suggest its effects are multi-faceted and complex.
Torcetrapib did not have a contractile effect on vascular smooth muscle suggesting its effects in vivo are via the release of a secondary mediator.
However, we did not see a significant increase in GO terms related to these functions, which is consistent with data suggesting its effects are not mediated through the transcriptional program [ 44].
