Moreover, recent data suggests that interrogating Plk1 PBD function by expressing a highly specific, suicidal PBD-binding peptide can potently induce mitotic block and apoptosis in tumorigenic or metastatic cancer cells, but not in normal cells (Park et al. 2015).
Recent evidence emerging from studies in which the tumour environment was interrogated suggests that a more fundamental driver of resistance is intratumoural heterogeneity (Ding et al, 2012; Navin et al, 2011; Ruiz et al, 2011; Xu et al, 2012).
These interactions suggested that the query genes we interrogated have distinct functions in the DNA damage response.
It is suggested that circularity can be avoided by interrogating anatomically defined regions of interest [ 29].
We and others have previously suggested that it might be more appropriate to interrogate the gene lists for biological themes, rather than individual genes [ 8, 12- 19].
The Saudi ambassador to Lebanon, Ali Saeed Asiri, said Majid was still being interrogated by his Lebanese captors but suggested that the kingdom might try to extradite him.
Friends of Travis said he complained Jodi was stalking him, and he even eerily suggested that if he showed up dead, Jodi should be interrogated.
After the tests, through the weekend, the former dictator is scheduled to be interrogated by an investigative judge, but his lawyers have suggested he will plead not guilty to involvement in murder and kidnapping.
The BBC journalists Justin Webb, Eddie Mair and John Simpson have suggested in recent weeks that not enough was done by the broadcaster to interrogate the sometimes outlandish claims made during the referendum campaign.
He suggested that the Muslim communities he knew felt "under siege" – spied on, interrogated, routinely asked to "put their house in order" as if they were not, and had never been, an equal part of British society.
