It was demonstrated that one group of antimitotic agents, vinca alkaloids, bind with similar affinity to all β-tubulin isotypes [ 12], thus suggesting for therapy with vinorelbine, vinblas-tine, or vincristine that tubulin isotype levels are incidental for efficacy.
This approach is also suggested for FON therapy.
The omni-directional cancer treatment program (OCTP) is suggested for the therapy planning in which all cancerous cells are killed without damage to normal cells.
A key area of research in the use of RNAi for clinical applications is the development of a safe delivery method, which to date has involved mainly viral vector systems similar to those suggested for gene therapy.
The TP targeting has been suggested for antiangiogenic therapy in tumours (Bronckaers et al, 2009; Bijnsdorp et al, 2011).
Cardiac glycosides have been suggested for cancer therapy, due to their potential to induce tumor specific cell death [ 38].
Cardiac glycosides have been suggested for cancer therapy, and their stimulatory effect on autophagy may be important in this context.
A "critical window" hypothesis has been suggested for hormone therapy effects on dementia, with benefits from initiation in the perimenopausal period but harms from later initiation [ 60].
A cell source that has been suggested for such therapies is that of autologous disc cells harvested from adjacent nondegenerate discs, although removal of cells from a donor disc can induce degeneration, and thus would be unsuitable [ 13].
Several explanations could be suggested for why NSAID therapy is less deleterious for fracture healing in some patients than in others.
43 Metformin is also the cornerstone of treatment in the American Diabetes Association/European Association for the Study of Diabetes algorithm, but either a sulfonylurea or insulin is suggested for add-on therapy, with the latter recommended for patients with HbA1c >8.5%.
