In addition, it has been reported that senescent microglia does not perform its actions properly (e.g. it presents a shortening of the telomere), a fact that has also been suggested for the PD brain (Barcia et al., 2004; Ouchi et al., 2005; Mount et al., 2007; Marinova-Mutafchieva et al., 2009; Cunningham, 2013).
One limitation concerns the size of our subject sample, which although allowed identification of robust findings was slightly smaller than the optimal fMRI sample size suggested for investigation of brain-behaviour relationships [71].
Therefore, miRNA expression patterns may be applied as a developmental marker of silkworm individuals, as suggested for the developing mammalian brain [ 33].
Transfusion threshold levels of up to 100 × 10/l have been suggested for treatment of severe brain injury and massive haemorrhage, but the evidence for the higher threshold is weak [ 275, 276].
The existence of cancer stem cells has been suggested for breast, prostate, colon and brain cancer.
PSp was one of the two possible adult brain areas suggested for AF7 based on its location in classical dye tracing work (Burrill and Easter , 1994.
A higher target level of 100 × 10/l has been suggested for those with multiple trauma, brain injury and massive bleeding [ 383, 384].
Brain MRI is suggested for almost all migraine with aura sub-forms based solely on their rarity and concern with accurate diagnosis.
However, it could also be β-catenin-independent LEF1 or WNT functions [ 34– 36], as suggested for the latter in breast cancer brain metastasis [ 14, 15].
The C9ORF72 expansion could also have an impact on early brain development, as suggested for the trinucleotide repeat in Huntington's disease 22. Screening by PCR can detect the repeat expansion, but Southern blots will be required to demonstrate genetic anticipation and determine the relationship between repeat length and clinical presentation.
