Exact(7)
These data suggested compound 1 might be a tricyclic diterpene.
Herein, the structure of two units was elucidated, and suggested compound 6 was a monocyclic polyketide derivative.
In vivo pharmacokinetic profiles suggested compound 12e showed a long half-life, which indicated that it could be administered intravenously.
The chemical shift values of 1D NMR of 1 were quite similar to those of the known compound 3β,12-dihydroxydrimenol (1a) [6], which suggested compound 1 possessed a drimane sesquiterpenoid skeleton.
Moreover, with the deep research of the drug pathway, it (the further mechanism researches) suggested compound 3a could inhibit the apoptosis of injured PC12 cells via blocking the mitochondria apoptosis pathway including up-regulation the ratio of Bcl-2/Bax, down-regulation the expression of cytochrome-c (Cyt-c) and inhibition of the activity of caspase-9 and -3.
Among them, compound (1b) possessed excellent activity (MIC 0.05 μg/mL) against M.tb H37Rv strain and exhibited low level of cytotoxicity against Vero cells, which suggested compound (1b) is a promising lead for subsequent investigation in search of new antitubercular agents.
Similar(53)
Chahkandi and Gangali (2009) first suggested compounding exponential and power series class, which exhibits decreasing failure rate.
The structural motifs of suggested compounds can emerge from the same polyyne building blocks as for experimentally fabricated expanded cubane.
Research has suggested compounds in dandelion root could have anti-cancer properties, and it's also high in vitamin C, vitamin D and beta carotene.
A difficulty in expanding the kinase libraries was to assess synthetic feasibility of the suggested compounds, especially if they contained novel cores.
Docking studies with human MAO shows that compound 11 interacts with the catalytic site of both the isoforms, suggesting compound 11 as nonselective inhibitor of human MAO isoforms.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com