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Bad slats, narrow passageways, uncomfortable cubicles, overcrowding, increased competition and "bulling" activity have been suggested as negative factors in dairy free-stall herds [ 39, 40].
Gfi1 (Ichiyama et al. 2009; Zhu et al. 2009), Ets-1 (Moisan et al. 2007), Foxo1 and Foxo3a (Ouyang et al. 2010; Wan et al. 2010) are also suggested as negative regulators of Th17 differentiation.
The multidrug resistance-related protein (MRP -type ABC transporters have been iMRP -type in the vABColar sequestransportershavelic compounds such as flavonoids and anthocyanins, and flavonoids have been suggested as negatimplicatedtors of MDR-type members (for revinw: [ 84]).
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The functional role of GS3 has been suggested as a negative regulator to prevent the growth of the grain size.
It has been suggested as a negative regulator in the differentiation-induced HPV-6 E1 promoter and the HPV life cycle (see also the link between YY1 and the long control region of HPV-16, as reported in [231]).
RAV1 has been suggested as a negative regulator of plant growth and development [ 45].
DNA methylation has been suggested as a negative regulator of recombination [ 25].
Age has been suggested as a negative prognostic factor in ALS, but our analysis shows this was not a determinant of the extent of TDP-43 pathology.
Ccng1 has been suggested as a negative feedback regulator of p53 [ 38], and therefore lower expression of Ccng1 in the DA rat would lead to more apoptosis in the lymph nodes just before arthritis onset.
Neither USP15 (also recently suggested as a negative regulator of mitophagy) nor USP33 or AMSH (implicated in autophagic and endo-lysosomal processes, respectively) enhanced CCCP-induced cell death in Parkin-overexpressing RPE1 cells [ 16, 29, 30].
Although this mechanism has not directly been verified in VSMCs, it has been suggested as a possible negative regulatory mechanism of Nox1 since both the signal (PKA) and the substrate (NoxA1) co-exist in this type of cell.
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Justyna Jupowicz-Kozak
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