This suggests a large scale phenomenon of methylation dysregulation in cancer, rather than a specific targeting of methylation change at given sites.
This distribution of the alignments in the nonrecombining region could potentially be interpreted to suggest a large scale inversion involving the majority of the mating-type chromosomes, followed by further localized rearrangements that obscure the inverse co-linearity of alignment order that is expected to result from such an inversion event.
A Tank Corps officer, Colonel J.F.C. Fuller, had already suggested a large-scale raid on the front southwest of Cambrai, where a swarm of tanks, unannounced by any preparatory bombardment, could be released across the rolling downland against the German trenches.
This suggested a large-scale dis-regulation of the pacemaking machinery.
Since there is no evidence to suggest a large-scale migration onto or off Long Island, historians believe that the native people that Europeans encountered when they arrived, in the sixteen-hundreds, were the direct descendants of the aboriginal inhabitants of the land, ten thousand years ago.
This passage from the abstract pinpoints the significance of the finding: The processes we report here … suggest a large-scale shift towards a structurally novel ecosystem absent for millennia, which shares many characteristics with that described for Beringia in the early Holocene epoch.
Like other ice cores from the Tibetan Plateau, Dasuopu suggests a large-scale, plateau-wide 20th-century warming trend that appears to be amplified at higher elevations.
The low frequency component of auto-correlation suggests a large-scale particle flow in both acceleration regime and fully-developed regime.
The massive accumulation of duplication events at the LCA of the Phytophthora genus suggests a large-scale duplication event that predates the speciation and hence might be driving the adaptive radiation within this genus.
These local results seem to suggest that a large scale implementation of diabetes education programmes at all levels of care could decrease the current disease burden and economic cost due to diabetes in Argentina and optimise resource use.
