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For the remaining 59 method/dataset associations, the predictiveness curves suggested a defect of association between the scores obtained by the compounds and their activity.
No upper and lower states for the transition were specified, but Tam et al. [11] have subsequently suggested a defect complex, e.g. VOZn i as the lower state in red/yellow PL.
These results suggested a defect in HSC self-renewal in the absence of Lsd1.
The inability of neb zebrafish to swim suggested a defect in muscle force generation.
Several phenotypes associated with these mutants suggested a defect in SPB duplication.
The decrease in colony size and number suggested a defect in the self-renewal of the LT-HSCs.
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Yeast cells bearing an arf1 null mutation display a number of phenotypes suggesting a defect in the secretory pathway.
The late recruitment of the V-ATPase in 3d/3d phagosomes might suggest a defect in phago-lysosome fusion.
Bcl-6 expression was higher in the PbAmif -infected mice, suggesting a defect in the maturation of these cells in the presence of PMIF (Fig. 2d).
At the protein level, α-Spectrin and Dystroglycan are misdistributed suggesting a defect in the costameric network.
An imbalance in macrophage polarization towards the M1 pro-inflammatory phenotype is also found in CF patients or in Non-CF cells treated with CFTR inhibitors, suggesting a defect in the STAT-6 signalling74.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com