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Our data suggest a complex interplay between mechanisms of local peripheral tolerance and innate antitumor mechanisms possibly involving NK cell allorecognition as a basis for the differential growth or rejection of B16 tumors in these unique chimeric mice, which we suggest to constitute a valuable new model system for the study of immune-mediated tumor rejection.
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Endothelial progenitor cells (EPCs) have been suggested to constitute a restoration index of the disturbed endothelium in ICU patients.
A delay in the time to peak intensity has been suggested to constitute the most accurate parameter for studying cerebral perfusion in cerebrovascular disease because its value shows low intraindividual variability and is not influenced by the depth of the insonation plane [6, 12].
More recently, however, productive infection by pH-independent, clathrin-dependent endocytosis of HIV-1 has also been reported and was recently suggested to constitute the only route of productive entry.
The DAT KO mouse has been suggested to constitute an animal model of several disorders thought to involve hyperdopaminergic function, including schizophrenia [2], [99], which would be consistent with a "hypofrontal" phenotype.
As the most recent addition, Cortinogaster was suggested to constitute a novel genus closely related to Cortinarius but as yet remained unpublished and is currently termed "Hymenogaster sublilacinus" [8] in Genbank, which is not an authoritative source for taxonomy.
Similarly, BCL2, one of the genes whose overexpression has even been suggested to constitute a molecular marker of synovial sarcoma [48], [49], was induced in two batches of MSCs (batches 2 and 4) but not in the other two.
CRISPR loci, Cas (CRISPR-associated) proteins, and leader sequences (the non-coding sequences flanking the CRISPR loci on one side and acting as a promoter) [21], were suggested to constitute a prokaryotic immune system against bacteriophage attack.
Main directions of phenotypic variance are suggested to constitute "lines of least resistance" to evolution [44], by representing morphologies more frequently produced in a population due to genetic or developmental factors, and hence more easy to screen by selection or to randomly sample by drift.
Anxiety, inattention and social problems have been suggested to constitute a "preterm behavioral phenotype" [ 13].
Myeloid-derived suppressor cells (MDSCs) have been suggested to constitute tumor-favoring microenvironments.
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CEO of Professional Science Editing for Scientists @ prosciediting.com