Animal models devised in rodents, sheep, cattle, or other domestic animal species have the advantage of being biologically "complete," but all differ to some degree in developmental timing and anatomical details compared to the human, suggesting subtle differences in molecular mechanism.
Curiously, wild-type RH is enriched for in vivo specific bradyzoite markers, but not in vitro specific genes, suggesting subtle differences in mRNA expression profiles.
A number of in vitro functional tests of immune cells suggested subtle differences between the animals on the outdoor versus indoor production systems.
By demonstrating that discriminant kinematic features of the observed grasping can predict the subsequent motor act, our findings strengthen the notion of motor chaining, and suggest that subtle differences in the observed movement kinematics may be useful in determining the most probable chain.
Additionally, our observations suggest that subtle differences in energy balance can, over time, significantly affect bodyweight and metabolic status in mice.
These data suggest that subtle differences in HIV-specific immunity exist between populations, with potential implications for approximating the breadth of vaccine coverage.
Observed data suggest that subtle differences in M. tuberculosis transmission and epidemiology may exist in Sichuan, making the overall population structure observed quite different from that observed in northern China.
Together with the experiments in the humanized PPARα mouse model, these in vitro observations suggest that subtle differences in the mPPARα and hPPARα receptors contribute to a species-specific PPARα-dependent metabolic response to DEHP.
Crystallographic studies of AMN107 indeed suggest that subtle differences in the mode of binding to Abl and a better topological fit to the Abl protein account for the greater potency of the drug (Weisberg et al, 2005).
