In silico experiments using all-atom simulations suggest that rigid body motions of protein subdomains couple the length changes of the crosslinker to rearrangements of the nucleotide-binding pocket, leading to cage opening.
These results suggest that rigid ligands that lack sufficient steric bulk are not able to activate the Kef system.
A thorough literature search did not find any evidence to suggest that rigid sports tape applied along the line of pull of the quadriceps femoris and triceps surae muscles would affect motor performance during repeated submaximal single-leg hopping and was considered an appropriate sham intervention as it was not applied over a joint to limit joint motion.
Both experimental characterizations of inter-chain spacing and microporosity and molecular modeling analysis of chain conformations and rigidity suggested that rigid H-shape pentiptycene units effectively disrupted chain packing, resulting in large fractional free volume and consequent high gas permeabilities in these membranes.
It seems likely from the story of the Phoenician tax farmers mentioned above that considerable authority lay in the hands of the wealthy; yet the fact that both Ascalon and Joppa issued Ptolemaic regal coinage, but apparently no autonomous bronze coinage, suggests a rigid control.
Other investigators have suggested less rigid cut-off values of p < 0.05 or p < 0.01 particularly for studies of the auditory system [37, 38].
Most of the specific inter-FU interactions were localized at narrow regions in the FU dimers, suggesting that rigid FU dimers formed by specific interactions assemble with flexibility.
The peroxide-resistant cells are diploid rather than aneuploid, show fundamental changes in the cytoskeletal cellular structure, suggesting less rigid more flexible cells, express a new lower molecular mass of p53, a key stress protein responder involved in adaptation, and finally have an immunochemical modification in αA-crystallin, a small heat-shock protein.
We observed a concerted movement of TM helices within domains D1 and D2 during the simulations, suggesting a rigid body movement of these domains.
There is no evidence of significant conformational changes occurring in either the Ley carbohydrate antigen or the hu3S193 binding site, which suggests a rigid fit binding mechanism.
