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While his proposal suggests reclassification is possible, "it's immensely unlikely that he's willing to go the extra mile such a push would require," Karl Bode, a telecom analyst, wrote last week on his blog DSL Reports.
However, several studies have suggested potential reclassification of cobalt-based alkyd driers.
Additionally, work also suggests that reclassification, may be important when determining the incremental predictive validity of a novel risk marker.
The inclusion of serum omentin-1 levels in the prediction model (includes age, gender, NYHA functional class, left ventricular ejection fraction, and serum BNP levels) for the prediction of cardiac events, improved the NRI and IDI values, suggesting effective reclassification and discrimination (Table 4).
We're not aware of any evidence to suggest that the reclassification of DSM as mechanically separated meat in the UK has led to the contamination of beef products with horsemeat.
These findings, taken together, suggest that our proposed reclassification is not merely a mathematical model function; rather it is tracking real underlying molecular sarcoma "phenotypes" based on tissue differentiation lines.
As shown in table 3, however, the integrated discrimination improvement index was positive and significantly different from zero, suggesting improvement in reclassification, when the conventional model was compared with models incorporating all three MRI variables (integrated discrimination improvement 0.043; z=2.11, P=0.04) or hippocampal volume (0.044; z=2.23, P=0.03).
In addition, preliminary data suggest some unintended effects of de-registration of drugs or upward reclassification of specific medicines.
Thirdly, although our findings suggest that the use of HbA1c for diagnosis will result in reclassification of different numbers of individuals in different ethnic groups, it remains unclear if this reclassification does or does not result in the appropriate identification of persons at higher risk of diabetes-associated complications.
The current data suggest that further discussion is needed because using A1C alone will lead to a reclassification as normal of many patients who previously (i.e., using IFG) were considered to have pre-diabetes.
In fact, recent recommendations suggest that ER and PgR assays be considered positive, for therapeutic purposes, if there are at least 1% positive tumour nuclei [ 48], but these data were not available for the majority of carriers in our samples to enable reclassification.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com