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Several computational methods exist to suggest rational genetic interventions that improve the productivity of industrial strains.
Several methods can suggest rational interventions that may lead to favourable industrial phenotypes (see [ 1] for a review).
Furthermore, these results suggest rational combinatorial strategies for targeting RTK signaling pathways more effectively, which has potentially important implications for cancer therapy.
14 15 Identifying ITR may also highlight promising drug combinations for combination therapy, and suggest rational molecular criteria for patient inclusion and exclusion in clinical trials.
As these trends are often associated with local treatment practices [ 22, 23] therefore, we suggest rational use of broad-spectrum antibiotics especially carbapenem and vancomycin to prevent increasing resistance against them.
Given the broad biological and clinical significance of the bacterial cell-envelope, acquiring a more complete understanding of its components and their associations should suggest rational new targets for antibiotic development.
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But, as Mr. Bennett suggests, rational arguments are not enough to change our societal reality.
Since several politicians, as well as the auto executive William Ford, suggested rational gasoline taxing 25 years ago, our failure to do so has had huge consequences, including the disconnected suburbs and the decline of "mom and pop" stores cited by Mr. DeArment and Mr. Johnson.
For instance, evaluation of the clinical features of carriers of mutant LMNA in kindreds with familial partial lipodystrophy suggests rational, staged intervention using established pharmaceutical agents to prevent cardiovascular complications not just for patients with lipodystrophy but by extension for patients with the common metabolic syndrome.
In this movement, authors such as Lee et al. [ 10] have suggested rational and planned approaches to adapt programs to different contexts.
The present analysis suggests rational, evolution-driven bases for engineering oncolytically superior strains of F and HN glycoproteins of Newcastle disease virus for cancer therapy [ 50], which will be presented separately, as will an analysis of HA flu evolution.
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