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Our overall results suggest null association of α-adducin G460T and GNB3 C825T polymorphisms with hypertension in Chinese but indicate local marginal significance of C825T, as a putative salt-sensitive switch, in southern Chinese.
Most prospective studies in this field suggest null associations between prenatal PCB exposure and weight, weight adjusted for height, or BMI in boys (Tang-Péronard et al. 2011).
Point estimates suggested negative associations between neighbourhood walkability and steps/day (eg, highest vs lowest GIS-derived walkability quartile: −234 steps/day, 95% CI −630 to 163; highest vs lowest Walk Score quartile: −232 steps/day, 95% CI −631 to 167), but CIs suggest null associations (table 3).
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Taken together, our overall associations suggested null association of α-adducin G460T and GNB3 C825T polymorphisms with hypertension in Chinese, whereas we locally indentified marginal significance for C825T, as a putative salt-sensitive switch, in southern Chinese.
MICRO-CHECKER suggested null alleles for loci including AV-021012, AV-021049, and AV-021224 (Table 2).
However, there were no general patterns suggesting null alleles at these loci, although we cannot rule out that null alleles may be present at varying frequencies among populations.
The conventional design may suggest separating null responders from the second trial and conducting a third single arm, a historical controlled trial for the null responders.
For example in the case of a vaccination campaign where coverage is of major interest, the population (analogous to the consumer) should suggest a null that would define the cutoff where coverage is inadequate.
Taken together, these facts strongly suggest that null SC5DL mutations could cause RG syndrome in humans.
Altogether, these lines of evidence suggest that null alleles are probably not the main cause for the observed deficits of heterozygotes within populations.
Secondly because problems with amplifying the MSP1 suggest the null mutations may be present which will artificially increase Fst at that locus in a manner that cannot be separated from the actions of immune selection.
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