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While these studies suggest inefficient transmission of current H5N1 viruses to humans, additional studies in individuals who are highly exposed to infected birds are essential to determine the full clinical spectrum of human H5N1 infections and assess the pandemic risk.
The near absence of lysosomal autophagosomal fusion and strikingly low expression of LAMP1 in the build-up area suggest inefficient local lysosomal biogenesis.
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In these metabolomics studies, such perturbations were ascribed to the depletion of key metabolites in glycolysis and cofactors (among other important metabolic variations) suggesting inefficient metabolic states such as carbon starvation, and diminished biosynthetic capacities (Bergdahl et al. [2012]; Matsushika et al. [2013]).
Indeed, counterintuitive to expectation, our observation that a ub-Fur4 fusion can rescue the sorting defect in ubp2Δ mutants suggests inefficient or improper ubiquitination of the internalized transporter.
Even at such low lactation pressure, the pup survival was affected in the HT7KO suggesting inefficient lactation.
Again, this pattern of greater activity was not accompanied by an increased DLPFC amygdala/accumbens coupling, further suggesting inefficient neural emotion regulation in euthymic BD-I.
In this regard, Wardemann and colleagues [ 1] found that most early immature B cells were self-reactive, suggesting inefficient checkpoint regulation in lupus.
Western blot analysis revealed lower levels of p53 protein and its Ser-15 phosphorylated form, suggesting inefficient upstream p53 signaling as a possible cause of reduced apoptotic response.
Serum specimens were not available from patient B. We found no transmission of H5N1 to healthcare workers, despite the lack of infection control measures, which suggests inefficient human-to-human H5N1 transmission; similar results were found in Hanoi (5).
An increase in the HOMA index value of >2.89 is accompanied both by an increase in insulin secretion and by an increase in insulin requirement, which suggests inefficient secretion in response to insulin resistance.
Despite the large widespread distribution of HEV-shedding pigs and the possible role of farmed pigs as the main virus reservoir, the number of human hepatitis E cases in Europe remains low, suggesting inefficient virus transmission or lower pathogenicity of swine g3 strains than of g1 strains for humans.
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