Regulation overview suggests downstream regulator elements for DXR-mediating light response in the class of transcription factors, protein modification and protein degradation (Additional file 7: Table S6; Additional file 8: Figure S2).
In contrast, a significant number of genes showed coordinate down-regulation, suggesting downstream involvement in common pathways.
Informants from other cities had a mixed approach, although they referred to the wider determinants as the causes of health inequalities, they also suggested downstream interventions to address these.
Of interest, it has recently been shown that the MET receptor activating phosphorylation site was highly responsive to EGFRvIII levels in glioblastoma cells in vitro, suggesting downstream cross-activation of MET by mutant EGFRvIII (Huang et al, 2007).
71, 73 Other suggested downstream targets of PDK1 in breast cancer include SGK-3 (which was required for tumorigenicity in a subset of PIK3CA mutated breast cancer cells), p70 ribosomal kinase (an AGC kinase that can be directly phosphorylated by PDK1), and PLCγ1 (which directly binds to PDK1 and regulates cellular invasion in a PDK1-dependent manner.
Previous report on the discovery of ANGPTL receptor, LILRB2, suggested downstream activation of CAMK (calcium/calmodulin-dependent protein kinase -2 and -4 and subsequent recruitment of SHP-2 (a Src homology 2 domain containing non-transmembrane protein tyrosine phosphatase) in freshly isolated mouse spleen cells (Zheng et al., 2012).
Blood flow is regulated by downstream resistance vessels; therefore, our findings suggest that downstream vascular resistance in immediate recovery from submaximal exercise was unaffected.
These results suggest that downstream interactions are important for binary complex formation; however, altered binary complex stability is likely to have implications for the subsequent binding of dNTPs.
Reconstruction of signalling cascades upstream of these TFs allowed us to suggest the downstream targets of EGF signalling in these two types of cellular states, i.e. transgenicity and liver cancer.
CAGE data also suggest two downstream TSS clusters in exon 1.
