Exact(9)
Some material was observed within the flagellar pocket for both knockout cell lines; this may suggest defective lipid or other biosynthetic defects in these cells, but is also observed occasionally in wild type cultures.
Heart and brain defects observed in E8-E10 mousembryososuggestst defective cell migration, and/or reduced mechanical stability or turnover of contact sites.
These findings also suggest defective oVEMP pathways in migraineurs.
The aberrant numbers of nuclei, pyrenoids, eyespots and CVs again suggest defective cytokinesis.
18 Taken together our results suggest defective 'outside-in' integrin signalling.
Because these phenotypes suggest defective processing of mechanical signals, we tested whether mechanical integrity was affected in cells in which our top hit SMPD4 was knocked down.
Similar(51)
Fibroblasts from these patients exhibited nuclear morphology defects, mislocalised emerin and SUN-2 and impaired nesprin/emerin/lamin interactions, suggesting defective LINC complexes in these patients are the underlying cause of EDMD.
Raman measurements suggested defective structure of the mixed oxide solid solutions resulting in the formation of oxygen vacancies.
In addition, exogenous hCNT1 predominantly accumulated in intracytoplasmic vesicles in CCC suggesting defective cellular trafficking of hCNT1 as a contributing factor to transport deficiency.
This strongly suggests defective cellular migration during intercalation.
We found a frequent appearance of multiple pronuclei (PN) in the PARylation-inhibited embryos, suggesting defective polymerization of tubulins.
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