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"Consumer and investor confidence has been eroded by the outbreak of the virus, and disruptions to travel and cross-border trade suggest cumulative losses of more than $500m across (sub-Saharan Africa) in 2015, outside the three directly affected countries," the report said.
Goldman's benchmarks to evaluate house prices "suggest cumulative nominal home price declines of 15% to 30% over the next few years".
The age-dependent phenotypes suggest cumulative damage and this is consistent with our observation that dOpa1 mutation results in increased ROS production and accumulation in eyes[18].
There are currently at least six trends that suggest cumulative exposure assessment may, over time, become easier and more straightforward.
Longitudinal studies suggest cumulative risk for depression and intermittent recurrence over time [i.e. 40% over 9 years; [ 7]].
Results suggest cumulative deficits in non-verbal and information processing skills for children treated with CRT + chemotherapy, with other deficits remaining relatively stable over time.
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Our results using conditional logistic regression showed that age was associated with positive QFT-GIT and TST results and there was a trend to increased responses with increasing age for both tests suggesting cumulative exposure to Mtb.
The steady log-linear increase in age related heart disease mortality in men and women suggests cumulative effects of lifelong vascular injury and failure of repair mechanisms.
The lifetime risk of ovarian carcinoma in females carrying HNPCC mutations has been estimated to be up to 12%, with a recent report suggesting cumulative risks of 20% or higher for the MLH1 and MSH2 genes; however, risk may vary with the specific gene involved (Bonadona et al, 2011).
Moreover, tremor amplitude showed a non-linear increase in the degree of suppression with successive stimuli; tremor suppression was increased threefold if a stimulus was preceded by four stimuli with a similar phase relationship with respect to the tremor, suggesting cumulative, possibly plastic, effects.
Therefore, it is too preliminary to conclude that cardiac toxicity from losoxantrone results from cumulative exposure, and to suggest a cumulative dose at which this occurs.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com