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These data suggest combinations of AKT and IGF-IR/InsR inhibitors would be an effective treatment strategy against hormone-independent ER+ breast cancer.
The experiments can suggest combinations of mutations but they can't prove their case because the deliberate infection of humans is unthinkable.
This is in correspondence with leading treatment guidelines which suggest combinations of antipsychotics be used only as a last resort [ 27].
Finally although so far eGFR methods using creatinine levels only have been considered as sufficiently satisfactory, recent developments suggest combinations of creatinine and cystatin C in regression formulae as necessary improvements in GFR estimations [ 39].
Hence, mapping kinase activation patterns based on different experimental conditions and time points when measuring many genes/proteins at once in diseased/perturbed versus normal/control may directly suggest combinations of kinase inhibitors that would shift the cellular state towards a desired phenotype.
Current recommendations suggest combinations of two nucleoside reverse transcriptase inhibitors (NRTIs) plus either a non-nucleoside reverse transcriptase inhibitor (NNRTI) or a PI. 9 The choice of whether to use a PI or an NNRTI in children is still unclear and is being addressed in the PENPACT 1 study (a 4-year randomized trial which finished in 2009).
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Although FA was not used in the bolus 5-FU arm in this Intergroup study, there is no evidence to suggest combination of bolus 5-FU/FA isuperioror to 5-FU alone during radiation (Tepper et al, 2002).
The doctor suggests "combinations of drugs," and adds, "You should also be getting plenty of early nights and steering away from alcohol".
Blatner suggests combinations of produce and protein.
Therefore, Kluge et al. [94] suggested combinations of different available MRI techniques for the detection of pulmonary embolism [5].
In this study, a few participants suggested combinations of pedagogical strategies, where several PBL courses are offered along with courses presented in a more traditional way.
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