Rapid changes within the CRISPR arrays due to virus/host dynamics have been suggested based on analysis of viritope sequences identified in bacteria from an acid mine drainage ecosystem which show a high degree of variability.
Nevertheless, there are still unresolved questions concerning the metabolic fluxes and regulations in clostridia that need to be studied before a more grounded hypothesis can be made, especially as our study is the first to suggest, based on transcriptional analysis, a putative involvement of nitrogenase to the overall H2 production in this bacterial genus.
The function of the second identified domain (ImuB-C domain) is less clear, but the authors suggest, based on genomic context analysis, that it may be involved in binding damaged DNA structures and help recruit downstream components.
We document this motif and its link with PCBP3 in a new Figure in the manuscript and now suggest, based on the motif enrichment analysis, that a PCBP paralog, most likely PCBP3, may be mechanistically linked to the observed transcript stability.
Finally, a series of seven guiding principles for formulation design of lipid-based delivery systems are suggested based on an analysis of recent data generated in our laboratories and elsewhere.
Security strengths of the method were evaluated and practical means of implementation were suggested based on analytical analysis.
Finally, a tri-linear softening curve for UHPFRC was suggested based on inverse analysis and verified through comparison between the finite element analyses and the test data.
A conceptual framework is suggested based on the analysis of results, positioning the role of room acoustics in the influence of sound on task performance.
2 3, pp. 264 274, 1977.] suggested based on the analysis of albedo and color relationships on Mariner 10 images that very low contents of FeO (at about 3 6 wt%) and TiO2 (<1 wt%) could be present in the mercurian regolith.
Structural features for compounds with improved activity are suggested based on the analysis of the CoMFA and CoMSIA contour maps and the property map of the protein ligand binding site.
Concerning the mixing behaviour, thermodynamic parameters have been suggested based on the analysis of natural samples (e.g. Glynn 2000; Monnin and Cividini 2006) and theoretical calculations (Becker et al. 2000), and have been assessed experimentally [e.g. (Felmy et al. 1993)].
