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In addition, given that HDAC6 inhibitors are undergoing clinical studies for certain diseases, the data shown in this study suggest an importance for investigating the effectiveness of HDAC6 inhibitors for pancreatic cancer treatment.
These experiments suggest an importance for both N and C-terminal domains in 30S interaction.
These observations suggest an importance of transcriptional dysregulation in HD and other polyglutamine diseases (16, 17), although how it mediates neuronal cell dysfunction remains obscure.
In conclusion, our data further suggest an importance of central thyroid hormone signalling in depressive-like changes that can be targeted to improve available therapy of this syndrome.
The additional data showing expression of oMAP4 in brain suggest an importance for oMAP4 in organising the non-centrosomal microtubules in axon and dendrites that remains to be confirmed.
Thus all studies suggest an importance of niche differentiation/differential selection in shaping the composition of hybrid populations, although the frozen niche variation model was not better supported than the non-niche-based general purpose model.
Similar(53)
Contrary to the Podunajská lowland, which is situated eastwards towards the centre of the Pannonian Plain, broadleaf thermophilous trees such as Ulmus, Quercus and Tilia were almost absent in the study region, which suggests an importance of the bedrock for Late-Glacial forest vegetation.
This suggests an importance of these effectors in the pathogenic process directed to bacterial translocation out of the GI tract and the associated ability of the T3SS effectors to systemically intoxicate host cells and tissues.
Some are expressed, based on the presence of an aligning EST, and have homologs in Mlp, suggesting an importance.
This evidence suggests an importance in both STS and SULT1E1 activity in improving metabolic outcomes associated with obesity.
This suggests an importance of lipid metabolism in disease progression in a relevant subset of BC patients, which warrants further mechanistic investigation.
Related(20)
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com