In our present study, the intermediate HbA1c data suggested a time dependent effect including a transient lowering of HbA1c after approximately three months in the metformin group.
Moreover, their tests suggest a time-dependent phenomenon, attributing to these suspensions a thixotropic response [24].
Our results suggest a time-dependent, stimulus-specific regulation of mRNA synthesis mediated by ER.
The aforementioned observations, in combination with the IP and luciferase analyses at days 3 and 5 of differentiation, suggest a time-dependent threshold effect of Dll1-activated NICD interplay with Mef2C and Maml1.
The content of Evan's blue increased as early as 6h, and remained unchanged until 6h, but robustly increased at 48 h after stroke in the ischemic penumbra (Fig. 8), suggesting a time-dependent BBB leakage.
This result suggests a time-dependent propagation of the dioxin-regulated transcriptomic signal: we hypothesize that the changes in gene expression that occurred on day 1 cause some of the gene expression changes that occur on later days, which underlie the teratogenic effect of dioxin.
Similarly, the highest level of vWF protein occurred after the 40 minute exposure time, suggesting a time-dependent response trend for VEGF effects on vWF protein.
The measured fluorescence from samples of equine influenza virus-infected cultures taken at different time-points suggests a time-dependent behaviour of the immunofluorescence signal (fig. 3).
However, the observed AUC of 1.51 g l−1 h−1 was again much higher than expected, suggesting a time-dependent pharmacokinetic interaction between indisulam and capecitabine.
The main change found for the SRL treatment after 3 weeks was increased urinary protein, with additional increment after 9 weeks, suggesting a time-dependent effect.
A mucous cell signature in PND 3 whole lungs, which correlated with up-regulation of genes normally suppressed by Spdef over-expression, was also detected, suggesting a time-dependent activation of alternative pathways.
