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Comparing the incidence of detected tumours in much younger PDK1+/+ PTEN+/−mice with older PDK1K465E/K465E PTEN+/− animals did not suggest a major difference in the frequency of different tumours.
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This strongly suggests a major difference in higher-order chromatin organization between Xa and Xi territories.
This could hint towards a general phenomenon in dinoflagellates that should be investigated further, because it suggests a major difference in a basic metabolic pathway.
This suggests a major difference in the state of single-stranded DNA exposed during replication in these two phyla of bacteria.
Nevertheless, a predictive map of genetic variation across Ecuador suggested a major difference between populations inhabiting areas west and east of the Andes (Fig. 1B), which is consistent with known population structure (Marks et al. 2002; Milá et al. 2009).
The alternative splicing of this exon suggests a major functional difference between the two TACC2 isoforms, TACC2s and TACC2l [ 3], as well as a significant difference between TACC2 and its closest TACC family relative, TACC1.
Although follow-up studies suggested these calls made a major difference, just three percent of the organization's members participated.
The current evidence does not suggest any major differences in efficacy and long-term outcome in patients with resectable disease.
Stratification of resource availability by hospital category (normal/high volume) did not suggest any major differences (data not shown) except for the ability to undertake blood culture; available in 8/10 high-volume hospitals and 2/12 low-volume hospitals.
This suggested the ABCC and its predecessor made a "major difference" to productivity.
These results suggest that for a minor impost, employers can make a major difference to the lives of their employees.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com