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When sequence or structure comparisons fail to suggest a function, insights can come from discovery of functionally important local structural patterns.
Our findings may suggest a function of KYNA and KYNAA2, in the used doses, in glutamatergic and nicotinergic neurotransmission.
In contrast, studies on the yeast Lgl homologs, Sro7/Sro77, suggest a function in exocytosis through interaction with the t-SNARE Sec9.
The up-regulation of IRF8 may suggest a function for miR-142 in the specification of CD4+ versus CD8α+ cDCs through regulation of the IRF8 pathway (Mildner et al., 2013).
Gene expression profiles suggest a function for AKH signaling in regulating Glossina energy metabolism, where AKH peptides are released from the corpora cardiaca and activate receptors mainly expressed in the fat body.
Recent studies suggest a function of microtubule-interacting proteins in modulating cancer cell sensitivity to microtubule-targeting drugs, although the precise molecular mechanisms remain elusive (Mohan et al., 2013; Rouzier et al., 2005; Sun et al., 2012; Veitia et al., 2000; Wagner et al., 2005; Wang et al., 2009).
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OsWRKY11 is induced by pathogens, drought, and heat, suggesting a function in biotic and abiotic stress responses.
Access network discovery and selection function (ANDSF) suggests a function for selection of access network and control offloading amongst 3rd generation partnership project (3GPP) and other access networks.
This result strongly suggests a function of PR-1a in HLR.
The low-molecular-weight GEFs are not found in the yeast, suggesting a function specific to higher eukaryotes.
A recent study similarly suggests a function related to flowering time for Arabidopsis AGL6 [ 15].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com