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The model is sufficiently tractable to solve analytically.
I'll argue that this style of modeling can be sufficiently fruitful, and sufficiently tractable, to make it worth pursuing.
Even these methods are not sufficiently tractable to process the millions of trees one would need for inference on genomic scales.
This optimization problem was sufficiently tractable to be solved by the simplex-based search procedure fmincon in Matlab, using repeated runs from different initial conditions, as described in the Methods section.
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To detect sequencing errors other than homopolymer errors, one must return to raw sequence data, but the candidate list can be shortened sufficiently to be tractable experimentally without having to do this (Table S4).
The model is mathematically tractable, yet is sufficiently complex to describe the segregated nature of the infection process.
We should construct multi-rate codon models that match the performance of REV in a statistical sense, with comparable likelihood scores, but with sufficiently few parameters to be computationally tractable and estimable from reasonable alignments.
The choice of the function g is problem dependent, but it should be sufficiently structured in order to make the optimization problem in 18 tractable.
To date, there are no studies that fulfill the design criteria necessary to test this idea, namely: having a large sample size; being sufficiently longitudinal; and using measures of processing efficiency that have a tractable biological basis, are grounded in theory, and are not themselves complex or based on motor response speed.
Microarray analyses have matured sufficiently in terms of accessibility and cost to make their application to this question tractable.
The complexity inherent in these systems challenges the modeling community to provide tools that capture sufficiently the richness of human and ecosystem processes and interactions in ways that are computationally tractable and understandable.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com