A simulation reveals that the inward current might depolarize the fibre sufficiently to trigger calcium release in the absence of an action potential and therefore cause an electrically silent depolarization-induced muscle contracture.
By contrast, proofreading may be less efficient when focal bases are flanked by a G or C. G/C nucleotides stabilize the pairing between strands and may thereby facilitate mismatched base pairs, as a mismatch will be less likely to destabilize the helix sufficiently to trigger proofreading.
By interfering with the inhibition of NF-κB by IκB, TCL1A may increase the concentration of free NF-κB molecules sufficiently to trigger expression of anti-apoptotic genes.
Thus, even at the peak of the action potential the non-L-type Ca2+-channels do not activate sufficiently to trigger exocytosis (Fig. 2A).
This apparent disagreement was resolved by showing that PGE2 levels did not accumulate sufficiently to trigger MMP induction in our experiments.
It is well-established that numerous apoptotic stimuli, including ROS generation, initiate apoptosis by disturbing mitochondrial function sufficiently to trigger leakage of cytochrome c from mitochondria [ 50].
We suggest that a slow-release CQ formulation may permit a gradual increase in blood CQ concentration and sustain these levels sufficiently to trigger parasite PCD while minimizing the risk of toxicity associated with the transient distribution-phase spike in concentration.
It might be possible that our ischemic challenge was not sufficiently low to trigger a complete microcirculatory response.
Moreover, only wounds that are sufficiently large to trigger a wound inflammatory response over 48 h appear to trigger a pre-neoplastic proliferative response; small wounds show no increase above background, unwounded, levels (Supplementary Fig S5C).
When the viscous dissipation effect is neglected, the thermal performance of nanofluid is overrated as much as 60%, sufficiently serious to trigger an attention in the performance analysis.
