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Sonication of the sample reduced the number of cell doublets, but not sufficiently to replace gating on FSC/SSC (Supplementary Figure S1).
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As such, reductions in fire-related tree mortality are thought to be one of the primary mechanisms by which fuel treatments may be able to protect long-term forest carbon stocks, particularly when post-fire regeneration is not sufficiently dense to replace the trees killed during fire [15, 26].
If a segment of the nascent polypeptide is sufficiently hydrophobic to replace the αC2 helix, it would successfully engage SRP54.
In this series, imaging was not found to be sufficiently precise to replace viscoelastic-assisted gonioscopy in the diagnosis and evaluation of cyclodialysis clefts.
This is because free buffer from the bulk cytosol cannot diffuse into the wrinkles sufficiently fast to replace the Ca2+ bound buffer.
An rK39 antigen-based rapid diagnostic test was evaluated and found sufficiently accurate to replace the direct agglutination test and spleen aspiration as the first-line diagnostic procedure.
The authors concluded that SLNB is feasible after chemotherapy for node-positive breast cancer, but it is not sufficiently accurate to replace ALND [ 24].
Major technological hurdles must be overcome before noninvasive sensing technology will be sufficiently reliable to replace existing portable meters, implantable biosensors, or minimally invasive technologies.
Albeit a considerable effort have been invested in finding alternative non-invasive approaches, these have not been sufficiently succesfull to replace biopsy assessment.
The quantitative/qualitative microbiological agar diffusion technique used in this trial to determine serum concentrations of doxycycline has been regarded as sufficiently reliable to replace analytical conclusions derived from high performance liquid chromatography [ 19].
While the time needed to obtain such a biopsy may raise patient concerns [ 17], avoiding misdiagnosis based on clinical opinion in 8.8% (this study) to 10% [ 17] of women supports tissue biopsy in the absence of imaging techniques sufficiently mature to replace pathology assessment.
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