Exact(4)
Additional well-designed and sufficiently powered trials or observational studies are required to address the need to reduce errors associated with magnesium sulphate administration.
However, they are consistent with the possibility of a beneficial effect of low-dose calcium supplementation during pregnancy, and, therefore, highlight the need for methodologically sound, sufficiently powered trials to either confirm or refute this effect.
There is a lack of evidence for choroidal neovascularisation secondary to conditions other than age-related macular degeneration or pathological myopia, and there is unlikely to ever be sufficiently powered trials in these populations.
Owing to the rarity of choroidal neovascularisation secondary to conditions other than age-related macular degeneration or pathological myopia, there are unlikely to ever be sufficiently powered trials in these populations.
Similar(56)
This study, therefore, aimed to further explore the additional effect of the supplemented cognitive training in a sufficiently powered trial.
However, the observed differences in the subgroup on sick leave due to mental health problems are clinically relevant, and should be examined in a sufficiently powered trial.
Although some authors believe intermittent CYC and daily CYC to be of equal efficacy to induce remission, this remains unproven by a sufficiently powered trial.
The most important design for a future study, however, would be a sufficiently powered trial comparing acute phase CBT without subsequent continuation versus acute phase pharmacotherapy with subsequent continuation (the current standard of treatment).
Whilst there are many randomized controlled trials investigating medical interventions that target some of these areas, there is a paucity of sufficiently powered randomized trials involving multi-dimensional interventions focusing on environmental, behavioral, and early developmental factors [ 3].
Nevertheless, well-designed and sufficiently powered clinical trials dedicated to adjuvant treatments for rectal cancer remain justified in future to achieve a high level of proof in keeping with evidence-based medical standards.
These hypotheses need to be confirmed in separate and sufficiently powered clinical trials.
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