The lack of correspondence between mRNA/protein expression studies and genetic variation studies along with the multiple contradictory findings in sufficiently-powered analyses indicates that the relationship between genotype and response may not be a simple one-to-one function.
This means that the analyses were sufficiently powered (with a sufficient number of cases in the models) to reliably estimate the associations between predictors and outcome.
Replication analyses in sufficiently powered and independent datasets will help to resolve this issue.
Our study was sufficiently powered (at 80% power and α=0.05) to detect effect estimates in the range of ±0.2 or greater.
12 13 14 15 16 Two recent meta-analyses 17 18 and one sufficiently powered recent study 19 concluded that NRT are not effective in helping pregnant women to stop smoking.
However, it's unclear whether either study will be sufficiently powered to identify multivariable predictors of ESRD because those analyses depend on the number of events, not the number of patients.
Meta-analysis of individual patient data helps to avoid ecological bias, allows sufficiently powered subgroup analysis, and even allows powerful and reliable evaluation of treatment effects across individuals [ 13].
Hundreds of these were not identified by local-eQTL analyses in our F2 and HMDP cohorts, even though these approaches were sufficiently powered to identify the majority of such effects.
Based on the literature, with expected GSTM1 null genotype frequencies in controls of 0.55 and in cases of 0.66 (based on OR 1.2 from the meta-analyses), a sample size in excess of 420 in each group is sufficiently powered (at the 90% level) to achieve significance at the 0.05 level (two-tailed).
Post hoc power calculations were carried out to evaluate whether the study was sufficiently powered, and to inform future research.
There are few well-designed and sufficiently powered RCTs.
