It said manufacturers could be held liable for "failing to ensure the recall was administered sufficiently quickly and efficiently to place individual owners on notice of the need to stop driving their vehicles".
The Association of Motor Offence Lawyers said that whether the recall put drivers on notice of a specific defect was "a grey area", adding that the manufacturer could be held liable "for failing to ensure the recall was administered sufficiently quickly and efficiently to place individual vehicle owners on notice of the need to stop driving their vehicles".
Phenytoin metabolism can be saturated if sufficiently high doses are administered [ 10], but the Cmax values showed the dose proportionality in this dose escalation study.
Administered at sufficiently high doses, antibiotics rapidly kill sensitive bacteria unless they are phenotypically resistant, in such case, leading to treatment failure (Smith and Romesberg 2007).
When administered at sufficiently high doses, both anti IL-6 anti IL-6IL-6Rα (andumed to tanti IL-6Rαtranti IL-6Rα assumeduble IL-6Rα) toeatarget lead to the suppression of serum CRP and gut pSTAT3 in a time-dependent manner.
Despite this very limited drug indication, amifostine is well recognized as a potent cytoprotectant for many of the body's major organ systems when administered at sufficiently large doses (i.e., 300 – 500 mg/kg).
Although all statins, to a greater or lesser degree, have the potential to cause adverse events if administered in sufficiently high doses, or in combination with other medications that alter their pharmacokinetics [29], multiple long-term safety studies have shown that these drugs are well tolerated by the majority of patients.
As the number of required skills increases and the team grows in size, a single leader is not sufficiently capable of administering a large project since the leader may not have enough time to communicate with all of the team members.
One premise of the derived conclusions is that the administered perfluorocarbon was sufficiently oxygenated so as to have a substantial impact on PaO2.
Simulations show that if the treatment is administered for a sufficiently long period of time, the tumor size (P) and the carrying capacity (K) will decrease exponentially to reach a steady state.
