Sentence examples for sufficient variant from inspiring English sources

We evaluated the performance of IgC2N through a simulation study and assessed that it has at least 80% power to detect rare (1%) CNVs with sufficient marker coverage or sufficient variant size in datasets with larger sample size (N = 2000) while detecting common CNVs with similar size or marker coverage with datasets of smaller sample size (N = 200).

However, false positive and false negative detections often result from lack of sufficient variant evidence, contamination of the biopsy by stromal tissue, sequencing errors, and the erroneous classification of germline variation as tumor-specific.

These patients showed lower serum levels of MBL protein than the group with genetic MBL-sufficient variants (Fig. 4A).

According to previous studies [19], [28], [29], genotypes 0/0, 0/XA, and XA/XA were classified as MBL-low variants while the remainders were MBL-sufficient variants.

With 896,206 reads that passed filters, an average coverage of 105× was achieved; 88% of the samples were covered at a level sufficient for variant calling (more than 10 reads) in at least 80% of the target region.

We checked whether the amount of off-target mtDNA reads was sufficient for mtDNA variant detection.

Consequently, a single indication of pathogenicity in STEP3, although measuring different aspects of the protein function than the MMR assay, was deemed sufficient to confirm variant pathogenicity.

The fraction of bases mapping to the targeted exonic regions was fairly stable for all samples (approximately 60%) and the overall coverage depth per sample was sufficient for reliable variant calling.

Average depth of coverage in all candidate regions of shared homozygosity was sufficient for comprehensive variant detection (29- to 114-fold, Supplementary Material, Table S1) of all exons and for all known annotated genes within all candidate regions regardless of their size.

Even though we detected many different variants between our strains and the reference sequence, subtraction of strain specific background variants was sufficient to remove almost all non causative variants.

These deep sequencing methodologies employ the use of viral PCR amplicons to obtain a depth of coverage sufficient to detect variants which occur down to 0.1% frequency.