A single nucleotide change can be sufficient to transform a proto-oncogene into an oncogene that induces cell transformation, whereas an inhibiting mutation must affect the two alleles of a tumor suppressor gene to favor transformation [ 61].
In contrast to the transformation of HMEC-DD cells, one oncogenic event is sufficient to transform Rat1-DD cells, indicated by both anchorage-independent growth in vitro and tumor formation in vivo (Ni et al., 2012).
In contrast to the transformation of HMEC-DD cells, one oncogenic event is sufficient to transform Rat1 rodent fibroblasts expressing p53DD (Rat1-DD) cells, as indicated by both anchorage-independent growth in vitro and tumor formation in vivo (Ni et al., 2012).
The other worry is that even though Anderson would undoubtedly make England a stronger team it is really the batting which is the problem at the moment and despite his dogged improvements in this area they are surely not sufficient to transform his side's beleaguered fortunes.
In other words, being social is necessary but not sufficient to transform healthcare.
A freak inch of snow was sufficient to transform the brawny midfielder into the proverbial elephant on ice skates.
Protons interacting with the liquid metal target inside the reactor will produce neutrons with energy sufficient to transform long living fuel isotopes to those with shorter decay time.
This temperature was sufficient to transform all volatile chlorine, which amounts to 15% of total coal chlorine, to the gas phase.
Furthermore, overexpression of wild-type NSD2 is sufficient to transform NSD2-/ cancer cells in vivo and in mouse embryonic fibroblasts (MEFs) (Kuo et al., 2011).
This gain was higher as the number of layers increased and sufficient to transform shear-type failure to flexural-type failure.
Whether the use of a gmail account instead of one's official dot-gov account is sufficient to transform otherwise public records -- records that belong to the people -- into the personal property of government officials, will be decided soon by the Third District Court of Appeal.
