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These observations indicate that if integrity of the p19ARF/p53 pathway is crucial for establishing cell cycle arrest in FHL2−/− cell lines upon Ras expression, inactivation of Rb by increased cyclin/Cdk activity may be sufficient to reset their replicative lifespan.
However, when the receptor−transducer complexes are overexpressed in the cells to >10-fold levels, the adaptation system is not sufficient to reset the kinase activation level (6, 20, 21) (J. Sasaki and J. L. Spudich, manuscript in preparation).
Most of our subjects with ADHD were not drug naïve, and although all were medication-free for at least 1 week, the washout period may not have been sufficient to reset the dopamine system to a basal level.
Therefore, auxin-induced adventitious root meristem organization appears to occur independently of cell reorganization and division, and the capacity to re-enter the cell division cycle alone [ 21, 22] is not sufficient to reset the previous cellular state in non-competent cells [ 10, 15, 18].
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Various pharmacological strategies have been devised to accomplish one common goal which is to reset sufficient levels of urine osmolarity in order to obtain a positive free water clearance.
Prepare to reset your sights, dear reader.
"He wants to reset with Russia.
THE Obama administration has decided it's time to "reset the reset" with Russia.
Time to reset that alarm clock.
The intention was never to reset Russia".
"We need to reset the cost base.
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