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Reduction of function of the demethylases potently suppresses longevity and UPRmt induction, while gain of function is sufficient to extend lifespan in a UPRmt-dependent manner.
The peak concentrations of the hydroxyl radical provide a signal-to-noise ratio sufficient to extend the measurements to a variety of axial and radial locations relative to the flame front.
Further, it must be pointed out that for the practical implementation and in order to avoid an exception handling at the signal boundaries, it is sufficient to extend the original or intermediate signals by a single value at both boundaries.
Furthermore, our data show that increased trehalose storage alone is not sufficient to extend lifespan.
Nor is the increased trehalose storage associated with reduced IIS sufficient to extend lifespan.
Our study demonstrates that, despite the correlation between reduced dilp2 mRNA levels and lifespan-extension often observed, DILP2 reduction is not sufficient to extend lifespan.
Our findings do show clearly, however, that neither reduction in dilp2 RNA and DILP2 protein expression alone nor increased trehalose storage alone is sufficient to extend lifespan.
Downregulation of S6K alone is sufficient to extend life span in flies (Kapahi et al., 2004).
This result demonstrates that mir-71 is sufficient to extend lifespan.
Our current work establishes that reduced JH is sufficient to extend Drosophila lifespan.
Reduced juvenile hormone alone is sufficient to extend the lifespan of Drosophila melanogaster.
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